Author Archives: panglab

paper progressing through review

just received the notification that a paper, submitted to the journal of feline medicine and surgery, has come back from the reviewers with minor comments.


always good to have positive reviews with constructive criticism; all the better for the swift turnaround, with a time from submission of only 17 days. this is a first paper for marika & tatum, and marika is on a roll with a second paper in review.


textbook citation

spotted by michelle in a the latest edition (2015) of lumb & jones, THE veterinary anaesthesia reference text. this references our work (#200) showing a small increase in intraocular pressure (approx 5 mmHg) following induction of general anaesthesia with the neurosteroid alfaxalone. Whether such a small increase is relevant is debatable, as it remained within the normal range of intraocular pressure for dogs with healthy eyes. However, this change could have adverse consequences where the intraocular pressure is already raised or where minimal changes in pressure are tolerated. this paper was mentioned in the very first post on this page, here.



paper published – refinement of euthanasia in rats

very pleased to see this published in PLoS One. this paper represents the work of jessie, my first MSc student, and describes her considerable efforts in refining euthanasia in rats. unfortunately, the common practice of overdose of inhaled carbon dioxide is aversive and likely to be stressful or painful, or both.


this work ties in nicely with the recently published NC3Rs report of the Second Newcastle Meeting on Laboratory Animal Euthanasia that was held in 2013.

Mouse Specifics blog mention

Tom Hampton, at Mouse Specifics, very kindly mentioned us on his company blog following a very interesting chat at the 2016 CALAS-CALAM Symposium about improving euthanasia methods in laboratory rodents and peri-anaesthetic care in general. Their ECGenie is a nice example of hands-off data collection, minimising handling and stress.

Some of the work presented at the meeting has been accepted by PLoS One and will soon be in press.


hypothermia clinical audit and accompanying editorial published

very excited to have an editorial published alongside Nicole’s paper describing a clinical audit of hypothermia management.

Dr Alex Dugdale wrote a very nice editorial to accompany the paper, describing the potential for clinical audits to be performed in practice. Nicole’s paper describes her idea to assess and improve our management of post-operative hypothermia in dogs. with some small, practical changes in management we were able to reduce our time to return 75% of patients to a normal body temperature from 7.5 hours to 3.5 hours; not perfect, but a dramatic improvement.


Paper available through JSAP and as a preprint (there were important changes to the manuscript as we progressed through review). The editorial is free to access through the journal’s website.